MethylDetectR - A Translational Tool for Methylation-Based Health Profiling

This dataset includes reproducible code for the two applications related to the 'MethylDetectR' software. These .R files are included as 'MethylDetectR - Calculate Your Scores.R' and 'MethylDetectR.R'. An example DNAm file and SexAgeinfo file for upload to 'MethylDetectR - Calculate Your Scores' are included. These are 'DNAm_File_Example.rds' and 'SexAgeinfo_example.csv' respectively. An example output file from this application/for upload to 'MethylDetectR' is included as 'MethylDetectR - Test For Upload.csv'. An example and optional input file for case/control data is also available as 'MethylDetectR_Case_Control_Example.csv'. 

Furthermore, a script for the user to generate their own DNAm-based estimated values for human traits is included as 'Script_For_User_To_Generate_Scores.R'. A necessary associated file as 'Predictors_Shiny_By_Groups.csv' is also present for the script to run. We have also included separate necessary files to generate the chronological age predictor from Bernabeu et al. in our most recent versions of MethylDetectR. 

Lastly, an additional file called 'Truncate_to_these_CpGs.csv' is available which allows users to subset their methylation file to those CpG sites used in the 'MethylDetectR - Calculate Your Scores' application. This may substantially reduce the size of the methylation file for upload as well as its upload time.