Gold-Catalyzed Stereoselective Synthesis of Azacyclic Compounds through a Redox/[2 + 2 + 1] Cycloaddition Cascade of Nitroalkyne Substrates

We report a new redox/cycloaddition cascade on readily available 1-alkynyl-2-nitrobenzenes that produces complex azacyclic compounds stereoselectively. The core structures of the resulting products are constructed through a formal [2 + 2 + 1] cycloaddition among α-carbonyl carbenoids, nitroso species, and external alkenes.本研究报道了一种基于易得的1-炔基-2-硝基苯的新型氧化还原/环加成级联反应，该反应可立体选择性地生成结构复杂的氮杂环化合物。所得产物的核心骨架通过α-羰基卡宾、亚硝基物种与外源性烯烃之间的形式[2+2+1]环加成反应构建得到。