DNA-based NGS data for osteosarcoma.xlsx

Little is known about the molecular aspects involved in etiology and progression of osteosarcoma. In this study, next-generation sequencing (NGS) analysis in tumor tissue sample identified several single nucleotide variants (SNVs) in genes encoding tyrosine kinase proteins, which may have contributed to osteosarcoma development in an adolescent patient.目前学界对骨肉瘤（osteosarcoma）的病因及进展相关的分子机制所知甚少。本研究针对肿瘤组织样本开展下一代测序（next-generation sequencing，NGS）分析，在编码酪氨酸激酶蛋白的基因中鉴定出数种单核苷酸变异（single nucleotide variants，SNVs），上述变异或可促成该青少年患者的骨肉瘤发生。