Vitamin D receptor with a synthetic ligand ADRO2

Vitamin D receptor with a synthetic ligand ADRO2 Descriptor: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6R)-6-(1-adamantyl)-6-oxidanyl-hex-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor Authors: Otero, R, Numoto, N, Ikura, T, Yamada, S, Mourino, A, Makishima, M, Ito, N. Deposit date: 2017-07-12 Release date: 2018-07-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: 25 S-Adamantyl-23-yne-26,27-dinor-1 alpha ,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex. J. Med. Chem., 61, 2018

结合合成配体ADRO2的维生素D受体（Vitamin D receptor），其描述符为：(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6R)-6-(1-金刚烷基)-6-羟基己-4-炔-2-基]-7a-甲基-2,3,3a,5,6,7-六氢-1H-茚-4-亚基]亚乙基]-4-亚甲基-环己烷-1,3-二醇；该数据集涉及RNA聚合酶II转录中介体亚基1（Mediator of RNA polymerase II transcription subunit 1）与维生素D3受体（Vitamin D3 receptor）。作者：Otero R、Numoto N、Ikura T、Yamada S、Mourino A、Makishima M、Ito N。提交日期：2017-07-12；发布日期：2018-07-25；最后修改日期：2023-11-22。实验方法：X射线衍射（2 Å）。引用文献：《25 S-金刚烷基-23-炔-26,27-二去甲-1α,25-二羟基维生素D3：其维生素D受体复合物的合成、组织选择性生物活性及X射线晶体结构分析》，《药物化学杂志（J. Med. Chem.）》，61卷，2018年