MAPK signaling

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Description reference: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010 Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP382 CPTAC Assay Portal]

丝裂原活化蛋白激酶（MAPK）级联反应是一种高度保守的模块，它参与多种细胞功能，包括细胞增殖、分化和迁移。哺乳动物表达至少四组具有明显调控机制的MAPK，即细胞外信号相关激酶（ERK）-1/2、C端激酶（JNK）1/2/3、p38蛋白（p38alpha/beta/gamma/delta）以及ERK5，它们由特定的MAPKK激酶激活：MEK1/2激活ERK1/2，MKK3/6激活p38，MKK4/7（JNKK1/2）激活JNKs，以及MEK5激活ERK5。然而，每个MAPKK可被多个MAPKKK激活，这增加了MAPK信号传导的复杂性和多样性。推测每个MAPKKK赋予对特定刺激的敏感性。例如，生长因子激活ERK1/2依赖于MAPKKK c-Raf，但其他MAPKKKs可能在促炎刺激下激活ERK1/2。描述参考：KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010。本通路上的蛋白质可通过[https://assays.cancer.gov/available_assays?wp_id=WP382 CPTAC检测门户]进行针对性的检测。