Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension [Illumina]

To identify novel targets in left ventricular (LV) hypertrophy (LVH) we initiated comparative transcriptome analysis between genetic models derived from stroke-prone spontaneously hypertensive rats (SHRSP) and Fischer (F344). Previous genetic studies in the SHRSP/F344 model confirmed the presence of a major quantitative trait locus (QTL) for LV mass on rat chromosome (RNO) 1. We assigned carboxypeptidase X 2 (Cpxm2) to a genetic locus for LV mass identified in SHRSP. We assigned carboxypeptidase X 2 (Cpxm2) to a genetic locus for left ventricular mass.为识别左心室肥厚（left ventricular hypertrophy, LVH）的新型靶点，我们开展了卒中易感自发性高血压大鼠（stroke-prone spontaneously hypertensive rats, SHRSP）与Fischer（F344）大鼠遗传模型间的比较转录组分析。此前针对SHRSP/F344模型的遗传学研究已证实，大鼠1号染色体（rat chromosome 1, RNO1）上存在一个调控左心室质量的主效数量性状基因座（quantitative trait locus, QTL）。我们将羧肽酶X2（carboxypeptidase X 2, Cpxm2）定位至SHRSP品系中鉴定出的左心室质量相关遗传座位。我们将羧肽酶X2（Cpxm2）定位至左心室质量相关遗传座位。