Histamine and collagen regulation within the wound

Collagen accumulation in wounds is regulated by inflammatory mediators. An adequate inflammatory reaction influences deposition of that protein within granulation tissue of the wounds. The aim of the present study is to check whether histamine my influence collagen deposition acting directly on myofibroblasts derived from granulation tissue of the wound. Moreover, we plan on identifying the histamine receptor involved in this process.

伤口内的胶原蛋白积累受炎症介质（inflammatory mediators）调控。适度的炎症反应可影响该蛋白在伤口肉芽组织（granulation tissue）中的沉积。本研究旨在探究组胺（histamine）是否可通过直接作用于伤口肉芽组织来源的肌成纤维细胞（myofibroblasts），进而影响胶原蛋白沉积。此外，本研究还拟鉴定该过程中所涉及的组胺受体。