Introducing a New Class of N-Phosphoryl Ynamides via Cu(I)-Catalyzed Amidations of Alkynyl Bromides

We describe here the first synthesis of N-phosphoryl ynamides featuring C- and P-chirality via copper(I)-catalyzed amidative cross-couplings between phosphoramidates and phosphordiamidates with alkynyl bromides. Also featured is a tandem aza-Claisen–hetero-[2 + 2] cycloaddition for the synthesis of N-phosphoryl azetidin-2-imines.本文首次报道了通过铜(I)催化磷酰胺酯（phosphoramidates）、磷二酰胺酯（phosphordiamidates）与炔基溴化物之间的胺化交叉偶联反应，合成兼具碳手性与磷手性的N-磷酰基炔酰胺（N-phosphoryl ynamides）。此外，本文还介绍了用于制备N-磷酰基氮杂环丁-2-亚胺（N-phosphoryl azetidin-2-imines）的串联氮杂-Claisen-杂[2+2]环加成反应。