QUICHE reveals structural definitions of anti-tumor responses in triple negative breast cancer

Contains preprocessed single-cell imaging data and metadata for Spain, Stanford, and NeoTRIP TNBC cohorts. `.h5ad` objects can be accessed using the read_h5ad function in anndata. For access to the raw imaging data and cell segmentation masks, see the BioStudies imaging repository under the accession S-BIAD1507 at https://www.ebi.ac.uk/biostudies/bioimages/studies/S-BIAD1507. Spain TNBC cohort (spain_preprocessed.h5ad) contains preprocessed MIBI-TOF imaging data of 314 primary TNBC tumors from five medical centers collected from CNIO. De-identified patient-level metadata can be found in `adata.obs`. Stanford TNBC cohort (stanford_preprocessed.h5ad) contains preprocessed MIBI-TOF imaging data of 142 primary TNBC tumors collected from the Stanford hospital. De-identified patient-level metadata can be found in `adata.obs`. NeoTRIP TNBC cohort from Ref. (https://doi.org/10.1038/s41586-023-06498-3) (nt_preprocessed.h5ad) was originally downloaded from the Zenodo data repository (https://doi.org/10.5281/zenodo.7990870) and contains 119 baseline samples profiled with imaging mass cytometry. De-identified patient-level metadata can be found in `adata.obs`.本数据集涵盖西班牙、斯坦福及NeoTRIP三阴性乳腺癌（Triple-Negative Breast Cancer, TNBC）队列的预处理单细胞成像数据与元数据。其`.h5ad`格式数据文件可通过anndata库的`read_h5ad`函数读取。若需获取原始成像数据与细胞分割掩码，请检索BioStudies成像数据库的S-BIAD1507号登录项目，访问链接为https://www.ebi.ac.uk/biostudies/bioimages/studies/S-BIAD1507。 西班牙TNBC队列（数据文件：`spain_preprocessed.h5ad`）包含来自西班牙国家癌症研究中心（Centro Nacional de Investigaciones Oncológicas, CNIO）下属5家医疗中心的314例原发性三阴性乳腺癌肿瘤的预处理MIBI-TOF成像数据。已完成去标识化处理的患者级元数据可于`adata.obs`中查阅。 斯坦福TNBC队列（数据文件：`stanford_preprocessed.h5ad`）包含来自斯坦福医院的142例原发性三阴性乳腺癌肿瘤的预处理MIBI-TOF成像数据。已完成去标识化处理的患者级元数据可于`adata.obs`中查阅。 参考文献[DOI: 10.1038/s41586-023-06498-3]中的NeoTRIP TNBC队列（数据文件：`nt_preprocessed.h5ad`）原始数据源自Zenodo数据仓库（DOI: 10.5281/zenodo.7990870），包含119例经成像质谱流式细胞术检测的基线样本。已完成去标识化处理的患者级元数据可于`adata.obs`中查阅。