Data of Viral Respiratory Diseases on Sorok Island during the Pandemic

Our study found a specific NLRP3 competitor (4,4′-diaminodiphenyl sulfone, DDS) for COVID-19 ARDS treatment. It combines clinical, theoretical, and statistical analyses of chemical and pharmaceutical knowledge of the interaction between the Dapsone and NLRP3. In addition, SARS-CoV-2 works as the inflammasome in the mesoscopic area.
They might be originated from T-cell activation caused by HLA polymorphism. It has been tentatively concluded that the Pandemic virus might act to induce inflammasome.

本研究发现了一种可用于新型冠状病毒肺炎（COVID-19）相关急性呼吸窘迫综合征（ARDS）治疗的特异性NLRP3竞争性配体（4,4'-二氨基二苯砜，DDS）。本研究整合了氨苯砜（Dapsone）与NLRP3相互作用的化学与药学知识，并开展了临床、理论及统计学分析。此外，严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）在介观尺度下可作为炎症小体发挥功能。此类炎性激活事件可能源自人类白细胞抗原（HLA）多态性引发的T细胞活化。研究初步推断，本次大流行冠状病毒可能具有诱导炎症小体产生的作用。