Uppsala Longitudinal Study of Adult Men (ULSAM)

Uppsala Longitudinal Study of Adult Men (ULSAM) is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924 and living in Uppsala County, Sweden. The aim of Uppsala Study of Adult Men (ULSAM) is to investigate the risk factors for common diseases, including biochemical markers, variations in the genome and life style factors. ULSAM started as a health investigation, focused at identifying metabolic risk factors for cardiovascular disease, to which all 50 year-old men living in Uppsala in 1970 were invited. Of these, 82% (2322 men) participated in the investigation. The men were thereafter investigated again at ages 60, 70, 77, 82, 88 and 93 years. In the 93 years investigation, which was completed in spring 2015, even spouses to the men from original cohort have participated. ULSAM is focused on several areas with a wide range of phenotypes collected. These areas include glucose and insulin metabolism, blood pressure, anthropometry, lipids and fatty acid composition, diet, cognitive function, socio-economic factors, heredity, medical history, and common risk factors for cardiovascular disease. In the latest investigation we are particularly focusing on the factors leading to healthy ageing. The longitudinal design of the study contributes to the collection of the same (or similar) phenotypes at several points in time. The loss of follow up end points is very low due to yearly matching with official cause-of-death and hospital discharge registries. Very important research area in ULSAM is analysis of genetic factors affecting common diseases. We have DNA samples available from more than 1200 men. Using modern genotyping technologies, these samples have been analyzed for over 2.5 million SNPs. We are also planning to perform whole genome sequencing for all individuals with DNA samples available. Large number of researchers are using ULSAM data in their studies. ULSAM is involved in several international collaborations as well. Over 300 articles have been published from ULSAM initiation in 1970 and at least 30 doctoral theses explored data collected in our study.乌普萨拉成年男性纵向研究（Uppsala Longitudinal Study of Adult Men, ULSAM）是一项独特的、持续进行的纵向流行病学研究，研究对象为1920年至1924年间出生、居住于瑞典乌普萨拉县的所有符合条件的男性。该研究的核心目标为探究常见疾病的各类危险因素，涵盖生物标志物、基因组变异及生活方式相关因素。 该研究最初作为一项健康调查启动，旨在明确心血管疾病的代谢危险因素，1970年时邀请了所有居住在乌普萨拉的50岁男性参与。最终有82%的符合对象（共2322名男性）参与了此次调查。此后，研究团队分别在这些男性年满60、70、77、82、88及93岁时对其进行了随访评估。2015年春季完成的93岁随访调查中，原始队列男性的配偶也参与了此次调研。 ULSAM涵盖多个研究领域，采集了丰富的表型数据，具体包括糖代谢与胰岛素代谢、血压、人体测量学指标、脂质及脂肪酸组成、膳食情况、认知功能、社会经济因素、遗传因素、病史及心血管疾病常见危险因素等。在最新的随访调查中，研究团队重点关注健康老龄化的相关影响因素。 本研究的纵向设计使得我们能够在多个时间点采集相同或相似的表型数据。由于每年都会与官方的死亡原因登记库及医院出院登记库进行匹配，研究的失访率极低。ULSAM的一项核心研究方向为分析影响常见疾病的遗传因素。目前我们已获取超过1200名男性的DNA样本，借助现代基因分型技术，已对这些样本中超过250万个单核苷酸多态性（Single Nucleotide Polymorphism, SNPs）进行了分析。此外，我们还计划对所有留存DNA样本的研究对象开展全基因组测序。 目前已有大量科研人员利用ULSAM的数据开展相关研究，该研究也参与了多项国际合作项目。自1970年启动以来，基于ULSAM的研究成果已发表超过300篇学术论文，另有至少30篇博士学位论文使用了本研究采集的数据。