Palladium-Catalyzed Synthesis of Nitrones Via Redox Cross-Coupling of Nitro Compounds and Alcohols

A novel methodology for the synthesis of nitrones via palladium-catalyzed redox cross-coupling of nitro compounds and alcohols is established. The protocol is a mild, convenient, ligand-free, and scalable synthesis method that can be compatible with various nitro compounds and alcohols. Nitrone is a significant multifunctional platform synthon which can be synthesized directly and efficiently via this tactic from commercially available and cheap raw materials.本研究建立了一种通过钯催化硝基化合物与醇的氧化还原交叉偶联反应合成硝酮（nitrone）的全新方法学。该合成策略条件温和、操作简便、无需配体且可规模化制备，可兼容多种硝基化合物与醇类底物。硝酮是一类重要的多用途平台合成子，可通过该策略以商业化易得且价格低廉的原料直接高效地制备得到。