Published Orthogonal Replication, Independent External Asymmetry Across BioGRID and CORUM, and Orthogonal DepMap Functional Validation of a Native Fracture-State Family in a Computational Longevity Discovery Pipeline (Trinity Claims #87-#132, 2026-03-30)

This version fixes the next mature external-validation milestone from the Trinity computational longevity-discovery pipeline. Claims #87-#132 establish an exact operational plateau for native fracture-state admission, orthogonal replication of the target TOP3A/RMI2/CCDC69 family in published huMAP3 layers, strong-core switch decomposition, exact same-core response algebra, a strict falsification protocol, an exhaustive assay scorecard, universal external quartet visibility, canonical stable scaffold convergence, independent external asymmetry across BioGRID and CORUM, and a final orthogonal functional-validation layer in official DepMap Public 25Q3 matrices. In BioGRID, the target remains uniquely preserved as a stable-to-fracture outsider frontier: 3_to_0 in the full release and 2_to_0 under the stricter MV-Physical slice. In CORUM outsider-level complex curation, the target remains the unique stable-only family, with stable outsider RMI1 returning 5 human complexes and fracture outsider PITRM1 returning 0. In official ScreenGeneEffect, CRISPRGeneEffect, and CRISPRGeneDependency matrices, the target is top-ranked by stable-minus-fracture outsider functional delta in all three matrices and is the only analyzable family positive in all three. This package contains the milestone reports, claim documents, source notes, extracted evidence tables, source files, and publication materials for the first cross-archive-plus-functional demonstration that the Trinity target carries reproducible independent external asymmetry and orthogonal functional validation. This is a computational discovery and preregistration package and not a completed causal validation study.本版本修复了Trinity计算性长寿发现管线（Trinity computational longevity-discovery pipeline）的下一成熟外部验证里程碑。第87至132项声明确立了天然断裂状态准入的精确操作平台、针对已发表huMAP3层（huMAP3 layers）中目标TOP3A/RMI2/CCDC69家族的正交复制、强核心开关分解、精确同核心响应代数、严格证伪协议、穷尽性分析记分卡、通用外部四重态可见性、规范稳定支架收敛性，以及BioGRID数据库（BioGRID）与CORUM数据库（CORUM）间独立存在的外部不对称性，并在官方DepMap Public 25Q3（DepMap Public 25Q3）矩阵中增设了最终正交功能验证层。在BioGRID数据库中，该目标作为稳定抗断裂的外来前沿始终得到唯一保留：全发布版本中为3_to_0，在更严格的MV-Physical切片（MV-Physical slice）下为2_to_0。在CORUM数据库的外来级复合物注释中，该目标仍是唯一仅存的稳定家族，其中稳定外来体RMI1对应5个人类复合物，断裂外来体PITRM1对应0个复合物。在官方ScreenGeneEffect（ScreenGeneEffect）矩阵、CRISPRGeneEffect（CRISPRGeneEffect）矩阵及CRISPRGeneDependency（CRISPRGeneDependency）矩阵中，该目标在三个矩阵中均以稳定减断裂外来体功能差值位列榜首，且是三个矩阵中唯一可分析的阳性家族。本数据包包含本次里程碑报告、声明文件、源注释、提取证据表格、源文件及相关出版材料，为首次跨档案加功能验证演示，证明Trinity目标具备可复现的独立外部不对称性与正交功能验证性。本数据包属于计算性发现与预注册数据包，并非已完成的因果验证研究。