Crystal structure of human Cathepsin L with covalently bound Calpain inhibitor III

Crystal structure of human Cathepsin L with covalently bound Calpain inhibitor III Descriptor: (phenylmethyl) N-[(2S)-3-methyl-1-oxidanylidene-1-[[(2S)-1-oxidanyl-3-phenyl-propan-2-yl]amino]butan-2-yl]carbamate, Cathepsin L, DI(HYDROXYETHYL)ETHER, ... Authors: Falke, S, Lieske, J, Guenther, S, Reinke, P.Y.A, Ewert, W, Loboda, J, Karnicar, K, Usenik, A, Lindic, N, Sekirnik, A, Chapman, H.N, Hinrichs, W, Turk, D, Meents, A. Deposit date: 2022-06-13 Release date: 2023-07-05 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67, 2024

人类组织蛋白酶L（Cathepsin L）与共价结合的钙蛋白酶抑制剂III（Calpain inhibitor III）的晶体结构。描述符：(苯甲基) N-[(2S)-3-甲基-1-氧代-1-[[(2S)-1-羟基-3-苯基丙-2-基]氨基]丁-2-基]氨基甲酸酯、组织蛋白酶L、二(羟乙基)醚（DI(HYDROXYETHYL)ETHER）……。作者：Falke, S、Lieske, J、Guenther, S、Reinke, P.Y.A、Ewert, W、Loboda, J、Karnicar, K、Usenik, A、Lindic, N、Sekirnik, A、Chapman, H.N、Hinrichs, W、Turk, D、Meents, A。沉积日期：2022-06-13；发布日期：2023-07-05；最后修改日期：2024-10-23。研究方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.8埃）。引用文献：《共价组织蛋白酶L抑制剂的结构解析与抗病毒活性》，《J.Med.Chem.》，第67卷，2024年。