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Palladium-Catalyzed Cascade Arene/Alkyne Annulation: Synthesis of Fluorene-Benzoxazine Derivatives

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A palladium-catalyzed cascade arene/alkyne annulation reaction for the synthesis of fluorene-benzoxazine derivatives is developed. This transformation involves a 6-exo-dig cyclization, a 1,3-oxazine vinylpalladium intermediate, and a C–H bond activation.

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2016-10-03
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