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Gene expression changes in anti-diabetic treated Zucker diabetic rats

Alliance of Genome Resources2026-08-01 收录

抗糖尿病药物转录组学

糖尿病药物作用机制

数据链接：

https://www.ncbi.nlm.nih.gov/gds/?term=GSE36714 数据链接链接失效反馈

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资源简介：

Transcriptional profiling of insulin-sensitive tissues comparing control untreated ZDF rat with ZDF rat treated with three different anti-diabetic drugs and ZLC rat.

应用场景：

胰岛素分泌调节

糖尿病药物作用机制

Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptid

NIAID Data Ecosystem70

Antidiabetic Rosiglitazone Remodels the Adipocyte Transcriptome by Redistributing Transcription to PPARg-Driven Enhancers [HTS]

抗糖尿病药物转录组学

脂肪细胞转录组

Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its widespread clinical use. Rosi functions as a high-affinity ligand for PPARg, the adipocyte-predominant

NIAID Data Ecosystem10

Context-dependent actions of Exendin-4 on Î²-cell function and dynamic changes in islet gene expression over time in vivo

细胞功能调控

糖尿病药物作用机制

Context-dependent actions of Exendin-4 on Î²-cell function and dynamic changes in islet gene expression over time in vivo

ChEBI2014-04-11 更新00

Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca 2+ -Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets

糖尿病药物作用机制

胰岛素信号通路

Oxothiazolidine carboxylic acid is a prodrug of cysteine that acts as an anti-diabetic agent via insulin secretion and the formation of the Ca2+-mobilizing second messenger, cyclic ADP-ribose (cADPR).

NIAID Data Ecosystem20

GLP-1 induced transcriptomic profile in INS-1 cells

糖尿病药物作用机制

胰腺β细胞转录组

Aim: The purpose of this RNAseq study is to gain insight into the effect that Glucagon Like Peptide-1(GLP-1) or BMS-21 (11 amino acid GLP-1 mimetic) has on the transcriptomic profile of an insulin sec

NIAID Data Ecosystem00

Gene expression changes in anti-diabetic treated Zucker diabetic rats

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