Kidney Injury Molecule-1 Is Associated with Contrast-Induced Nephropathy in Elderly Patients with Non-STEMI

Abstract Background Contrast-induced nephropathy (CIN) is associated with an increased risk of major adverse cardiovascular events (MACE), and the association between CIN and oxidative mechanisms is well documented. Objective This study aimed to evaluate the relationship between serum levels of kidney injury molecule-1 (KIM-1) and CIN in elderly patients with non-ST-segment elevation myocardial infarction (NSTEMI). Methods This study included a total of 758 patients with NSTEMI, who underwent percutaneous coronary intervention (PCI); 15 developed CIN after PCI, and another 104 were the control group, matched for age > 65 years. Baseline to 48-to-72-hour laboratory values and clinical outcomes were recorded. Patients were followed during one year. P values of摘要 背景：造影剂诱导肾病（Contrast-induced nephropathy, CIN）与主要不良心血管事件（major adverse cardiovascular events, MACE）的发病风险升高存在关联，且CIN与氧化机制之间的相关性已得到充分文献佐证。目的：本研究旨在评估非ST段抬高型心肌梗死（non-ST-segment elevation myocardial infarction, NSTEMI）老年患者血清肾损伤分子-1（kidney injury molecule-1, KIM-1）水平与CIN的相关性。方法：本研究共纳入758名接受经皮冠状动脉介入治疗（percutaneous coronary intervention, PCI）的NSTEMI患者，其中15例在PCI术后发生CIN，另有104例为年龄匹配的对照组（年龄＞65岁）。研究记录了患者基线至术后48~72小时的实验室检测值与临床结局，并对所有患者进行了为期1年的随访。P值