File S1 - B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity

SI1, 1H and 13C–NMR spectra of all compounds. Figure S1, Two views of compound 3a (luotonin A) docked in the topoisomerase 1 active site. Figure S2, Two views of compound 3b docked in the topoisomerase 1 active site. Figure S3, Two views of compound 3c docked in the topoisomerase 1 active site. Figure S4, Two views of compound 3d docked in the topoisomerase 1 active site. Figure S5, Two views of compound 3e docked in the topoisomerase 1 active site. Figure S6, Two views of compound 3f docked in the topoisomerase 1 active site. Figure S7, Two views of compound 3g docked in the topoisomerase 1 active site. (ZIP)