File S1 - B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity

SI1, 1H and 13C–NMR spectra of all compounds. Figure S1, Two views of compound 3a (luotonin A) docked in the topoisomerase 1 active site. Figure S2, Two views of compound 3b docked in the topoisomerase 1 active site. Figure S3, Two views of compound 3c docked in the topoisomerase 1 active site. Figure S4, Two views of compound 3d docked in the topoisomerase 1 active site. Figure S5, Two views of compound 3e docked in the topoisomerase 1 active site. Figure S6, Two views of compound 3f docked in the topoisomerase 1 active site. Figure S7, Two views of compound 3g docked in the topoisomerase 1 active site. (ZIP)SI1：所有化合物的1H核磁共振谱与13C核磁共振谱。 图S1：化合物3a（luotonin A）对接于拓扑异构酶1活性位点的两个视角视图。 图S2：化合物3b对接于拓扑异构酶1活性位点的两个视角视图。 图S3：化合物3c对接于拓扑异构酶1活性位点的两个视角视图。 图S4：化合物3d对接于拓扑异构酶1活性位点的两个视角视图。 图S5：化合物3e对接于拓扑异构酶1活性位点的两个视角视图。 图S6：化合物3f对接于拓扑异构酶1活性位点的两个视角视图。 图S7：化合物3g对接于拓扑异构酶1活性位点的两个视角视图。 （ZIP格式）