Gandouling ameliorates Wilson's disease associated liver fibrosis in mice by altering the faecal microbiome and metabolome

Individuals with Wilson's disease (WD) exhibit liver fibrosis, a basic pathologicalchange that was recently demonstrated to be dynamic and reversible. The gutmicrobiota markedly influences the occurrence of WD. Gandouling (GDL), apreparation for treating WD-associated liver fibrosis, is an efficient, patented traditionalChinese medicine. We sought to determine whether GDL may prevent liver fibrosis intoxic milk (TX) mice by assessing its ability to regulate intestinal flora, metabolites, andbarrier function.