Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound with literature RSK2 inhibitor indazole cyanoacrylamide compound 26 (soak)

Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound with literature RSK2 inhibitor indazole cyanoacrylamide compound 26 (soak) Descriptor: (2S)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]propanamide, Ribosomal protein S6 kinase alpha-5 Authors: Yano, J.K, Abendroth, J, Hall, A. Deposit date: 2022-04-14 Release date: 2022-07-20 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1. Acs Med.Chem.Lett., 13, 2022

MSK1的C端结构域与文献报道的RSK2（Ribosomal protein S6 kinase alpha-5）抑制剂吲唑基氰基丙烯酰胺类化合物26（浸泡法）共价结合的晶体结构。描述符：(2S)-2-氰基-N-(1-羟基-2-甲基丙-2-基)-3-[3-(3,4,5-三甲氧基苯基)-1H-吲唑-5-基]丙酰胺。作者：Yano, J.K、Abendroth, J、Hall, A.。提交日期：2022-04-14；发布日期：2022-07-20；最后修改日期：2024-10-30。实验方法：X射线衍射（分辨率2.8 Å）。引用文献：Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1，发表于《ACS药物化学通讯》（Acs Med.Chem.Lett.），2022年，第13卷。