Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [MultiDisease]

We report that well-defined xenograft models of leading sources of CNS metastasis (melanoma, breast cancer, lung cancer) undergo specific transcriptomic alterations upon entering the brain microenvironment. This dataset can be utilized to explore the mechanisms of tumor cell plasticity as well as the co-adaptation of the brain microenvironment to metastatic disease. Examination of the transcriptomic profiles of lung cancer, breast cancer, and melanoma models of brain metastatic disease and the resulting gene expression changes of the stroma in the tumor-bearing brain.