Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication: creating new models

This data repository provides code and general instructions for creating new LINE-1 (L1) insertion site models as described in Flasch, et al., 2019:https://www.sciencedirect.com/science/article/pii/S0092867419302338?via%3Dihub Please see file L1_Simulation_Files_help.docx for more detailed information. File L1Simulation_filelist.xlsx lists the files described in the Word file and found in L1Simulations.tar.gz. Required large file ChrmsALL_table_sortEN.bed.gz is found individually. Importantly, like the paper analysis, this file is specific to the hg19 version of the human genome. Please see the companion Zenodo data set10.5281/zenodo.8233858if you only want to access our insertion data and the resulting models we created.本数据集仓库提供了构建全新LINE-1（L1）插入位点模型所需的代码与通用操作指南，相关方法源自Flasch等人2019年的研究，原文链接为：https://www.sciencedirect.com/science/article/pii/S0092867419302338?via%3Dihub。 如需获取更详细的说明信息，请查阅文件L1_Simulation_Files_help.docx。 文件L1Simulation_filelist.xlsx列出了该Word文档中描述的、以及L1Simulations.tar.gz压缩包内包含的全部文件。 所需大文件ChrmsALL_table_sortEN.bed.gz可单独获取。需特别说明的是，与该论文的分析一致，此文件仅适用于人类基因组hg19版本。 若仅需获取本研究的插入位点数据及已构建的模型，请查阅配套的Zenodo数据集（10.5281/zenodo.8233858）。