Molecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia

ChEBI2016-07-30 更新2026-07-12 收录

B细胞急性淋巴细胞白血病机制

癌蛋白功能研究

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资源简介：

Molecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia

创建时间：

2016-07-30

Gene expression profiling of LMO2 associated T cell lymphoblastic leukemia induced by insertional mutagenesis

B细胞急性淋巴细胞白血病机制

癌细胞转录组

Aberrant co-expression of LMO2 and TAL1 is regularly found in T cell acute lymphoblastic leukemia (T-ALL). Here we describe a xenotransplant model for primary T-ALL cells derived from a patient who de

NIAID Data Ecosystem60

Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells

B细胞急性淋巴细胞白血病机制

BCR-ABL1

The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of ALL with a particularly unfavorable prognosis. Acute lymphoblastic leukemia (ALL) cells are derived from B c

NIAID Data Ecosystem50

Expression data of pediatric B-cell acute leukemias. Homo sapiens

白血病表观遗传学

B细胞急性淋巴细胞白血病机制

We investigated DNA methylomes of 227 pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profile

NIAID Data Ecosystem20

RNAseq of pre-T cells from control and Zfp36l1, Zfp36l2 double conditional knockout mice.. Mus musculus

B细胞急性淋巴细胞白血病机制

RNA结合蛋白调控T细胞发育

Purpose: Conditional knockout of Zfp36l1 Zfp36l2 early in lymphocyte development leads to a bypass of beta-selection and subsequently T cell acute lymphoblastic leukemia. This RNA seq experiment aimed

NIAID Data Ecosystem60

MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-cell Acute Lymphoblastic Leukemia. MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-cell Acute Lymphoblastic Leukemia

B细胞急性淋巴细胞白血病机制

基因功能与治疗靶点研究

Little is known about the roles of methyl-CpG-binding domain protein 2 (MBD2), a “reader” of DNA methylation, in T-cell acute lymphoblastic leukemia (T-ALL). Here, we investigated the role of MBD2 in

NIAID Data Ecosystem20

Molecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia

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