Human PDK1-PKCiota Kinase Chimera in Complex with Allosteric Compound PS267 Bound to the PIF-Pocket
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Human PDK1-PKCiota Kinase Chimera in Complex with Allosteric Compound PS267 Bound to the PIF-Pocket Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Arencibia, J.M, Froehner, W, Krupa, M, Pastor-Flores, D, Merker, P, Oellerich, T, Neimanis, S, Schmithals, C, Koeberle, V, Suess, E, Zeuzem, S, Stark, H, Piiper, A, Odadzic, D, Schulze, J.O, Biondi, R.M. Deposit date: 2016-12-22 Release date: 2017-01-18 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.41 Å) Cite: An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem. Biol., 12, 2017
结合变构化合物PS267且该化合物结合于PIF口袋的人源PDK1-PKCι激酶嵌合体复合物
描述符：2,3-二羟基-1,4-二硫代丁烷、3-磷酸肌醇依赖性蛋白激酶1（3-phosphoinositide-dependent protein kinase 1）、腺苷-5'-三磷酸……
作者：Arencibia J.M.、Froehner W、Krupa M、Pastor-Flores D、Merker P、Oellerich T、Neimanis S、Schmithals C、Koeberle V、Suess E、Zeuzem S、Stark H、Piiper A、Odadzic D、Schulze J.O.、Biondi R.M.
存入日期：2016-12-22
发布日期：2017-01-18
最后修改日期：2024-10-16
实验方法：X射线衍射（分辨率1.41埃）
引用：《靶向非典型蛋白激酶C亚型PIF口袋的变构抑制剂骨架》，ACS Chem. Biol., 12, 2017
创建时间：
2016-12-22
