Data obtained from the GWAS Catalog and Type 2 Diabetes Knowledge Portal.

For each homozygous occurring TPC2 polymorphism, traits were sorted by statistical significance (p value), and the top five traits were analyzed further. Effect sizes were used as reported or calculated from the odds ratio. Standard error of the mean was calculated using the qt() function in R. The data was subsequently used to generate genotype/phenotype-association forest plots, as illustrated in Fig 6. (XLSX)针对每一种纯合存在的TPC2多态性，按照统计学显著性（p值）对相关性状进行排序，并选取排名前五的性状开展进一步分析。效应量（effect size）采用文献报道值或由比值比（odds ratio）计算得到。均值的标准误通过R语言中的qt()函数计算获得。后续使用该数据集绘制基因型/表型关联森林图，如图6所示。（XLSX）