Data platform (genotyping data set) related to ERDF postdoctoral project No. 1.1.1.2/VIAA/4/20/718 "The role of vitamin D gene polymorphisms and its receptors in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis".
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<strong>Data platform </strong><strong>(genotyping dataset)</strong> <strong>related to the ERDF postdoctoral project No. </strong><strong>1.1.1.2/VIAA/4/20/718</strong><strong> “</strong><strong>The role of vitamin D and its receptor gene polymorphisms in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis</strong><strong>”.</strong> <strong>About the project and gathered data:</strong> The dataset contains genotyping data on 289 sex-balanced samples (approximately 60% women / 40% men)) were created at the the multiple sclerosis (MS) Clinic of the Latvian Maritime Medical Center (LMMC) in 2011 (disease duration of 1-51 years); the collection was updated within the framework of the ERDF MS project (2017-2020) and replenished during the ERDF postdoctoral project No. 1.1.1.2/VIAA/4/20/718 “The role of vitamin D and its receptor gene polymorphisms in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis” (2021-2023). For the <strong>Genotyping dataset </strong>relevant information for each patient from the MS disease cohort, referring to proteasomal gene genetic variations (microsatellites and SNPs): (HSMS006 <em>(PSMA6),</em> HSMS602 <em>(FAM177A1),</em> HSMS701 <em>(KIAA0391)</em>, HSMS702 <em>(KIAA0391)</em> HSMS801 <em>(KIAA0391)</em>, rs11543947<em>(PSMB5), </em>rs2277460 (mi110), rs1048990 (mi8)<em> (PSMA6),</em> rs1048990 (mi8)<em> (PSMA6),</em> rs2295826/rs2295827<em>(PSMC6),</em> rs2348071 <em>(PSMA3),</em> rs2071543, rs9357155 <em>(PSMB8),</em> rs17587<em>(PSMB9),</em> rs74421874 <em>(PSMD9); </em>rs9275596 from HLA region; vitamin D-related genes (VDR and GC) polymorphisms: rs2228570, rs1544410, rs7975232, rs731236 (<em>VDR</em>) and rs7041, rs4588 <em>(GC).</em>
