Disability as a determinant of fatigue in MS patients

ABSTRACT Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. Results: Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p摘要 疲劳是多发性硬化症（multiple sclerosis, MS）最为常见且致残性最强的症状之一。中枢、心理及外周因素均可参与疲劳的发生发展。研究目的：本研究旨在评估功能损害程度较轻的复发缓解型多发性硬化症患者的潜在疲劳影响因素。方法：本研究对比了39名伴或不伴疲劳的复发缓解型多发性硬化症患者的炎症标志物、呼吸压力、残疾状况与生活质量。结果：伴疲劳的复发缓解型多发性硬化症患者扩展残疾状况量表（Expanded Disability Status Scale, EDSS）得分更高（p = 0.002）。本研究观察到盖伊神经残疾量表（Guy Neurological Disability Scale）、多发性硬化症生活质量功能评估评定量表（Functional Assessment of MS Quality of Life Rating Scale）的结果与疲劳的发生存在显著相关性（p