Asymmetric distribution of centromeric components in midgut stem cells and their role in cell types with varying differentiating potential

CENP-A is a histone variant critical for centromere function during mitosis. We have analyzed CENP-A in stem cells of the fly intestine and found an symmetric inheritance of pre-existing and newly synthesized CENP-A. CENP-A and its loading factor CAL1 are essential in differentiated cells, suggesting non-mitotic roles

CENP-A（着丝粒蛋白A）是一种在有丝分裂过程中对着丝粒功能至关重要的组蛋白变体。我们对果蝇肠道干细胞中的CENP-A开展了分析，发现预存在与新合成的CENP-A存在对称遗传模式。CENP-A及其加载因子CAL1在分化细胞中不可或缺，这提示二者具备非有丝分裂相关的功能。