Metabolomic data of H460 and A549 cells after trametinib treatment

MAP kinse-ERK kinase inhibitor (MEKi) resistance remains unknown. We determined gene expression profiling in MEKi-resistant cells and MEKi-sensitive cells after MEKi treatment using UHPLC-MS/MS.

丝裂原活化蛋白激酶-细胞外调节蛋白激酶抑制剂（MAP kinase-ERK kinase inhibitor，MEKi）的耐药机制仍未明确。本研究采用超高效液相色谱-串联质谱法（UHPLC-MS/MS），对经MEKi处理后的MEKi耐药细胞与MEKi敏感细胞进行了基因表达谱分析。