HCT_116_CombinationTherapy_Pooled_Project__ENU_Mutagenesis

NIAID Data Ecosystem2026-03-12 收录

组合靶向治疗耐药性

ENU诱变

数据链接：

https://www.ncbi.nlm.nih.gov/sra/ERP107248 数据链接链接失效反馈

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资源简介：

ENU used to engender resistance to a combination of a MEK inhibitor and an Akt Inhibitor.

创建时间：

2021-02-04

Improving the sensitivity of ENU mutagenesis screens using inbred mice: implications for modifier gene discovery.

ENU诱变

基因修饰研究

Positional cloning of ENU-induced mutations has traditionally relied on analysis of polymorphic variation between two strains. In contrast, the application of whole genome sequencing (WGS) has enabled

NIAID Data Ecosystem70

Four embryonic phenotypes identified in ENU screen.

ENU诱变

胚胎表型鉴定

*Number of homozygote mutants observed at weaning from a heterozygote intercross established after outcrossing the G1 founder to C57BL/6J for several generations. Expected 25% for viable phenotype.**S

Figshare2015-12-02 更新50

Confirmed ENU–induced mutations that are potentially causative for the abnormal phenotype in each line.

ENU诱变

基因表型关联

The average amount of sequence obtained for each mutant was 80% of the 7.8Mb (one-fourth) of the 34 Mb region containing exons of annotated genes. The mouse gene symbol is shown. Location of lesion in

NIAID Data Ecosystem40

ENU19 WT:005:b:B6:G3

小鼠遗传学

ENU诱变

All pedigrees screened in the pipeline will be sourced from mutagenised C57BL/6NCr males. Breeding through to G3 should proceed. The ABS ENU Colony Coordinator will manage the breeding process follo

Research Data Australia60

ENU19 WT:004:b:B6:G3

ENU诱变

小鼠表型分析

All pedigrees screened in the pipeline will be sourced from mutagenised C57BL/6NCr males. Breeding through to G3 should proceed. The ABS ENU Colony Coordinator will manage the breeding process follo

Research Data Australia40

HCT_116_CombinationTherapy_Pooled_Project__ENU_Mutagenesis

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