Factorial analysis showing regions of statistical significant differences in functional brain activation.

Shown is the main effect in non-exercised rats of Lesion and the Lesion×Walk interaction (Groups: Lesion/Walk/No-ET, n = 9; Sham/Walk/No-ET, n = 10; Lesion/Rest/No-ET, n = 10; Sham/Rest/No-ET, n = 9). Also shown is the main effect in lesioned rats of Exercise and the Exercise×Walk interaction (Lesion/Walk/No-ET, n = 9; Lesion/Rest/No-ET, n = 10; Lesion/Walk/ET, n = 11; Lesion/Rest/ET, n = 12). Significance (*) for all entries is shown at the voxel level (P[39]: 5 (trigeminal n., motor, sensory), aca (anterior commissures), AHi (amygdalo-hippocampal area); APir (amygdalo-piriform transition area); BL (basolateral amygdala), Ce (central amygdalar n.), Cg (cingulate cortex), CM (central medial thalamic n.), CPu (striatum: anterior, ant-CPu; dorsal, d-CPu; ventral, v-CPu), d-HPC (dorsal hippocampus), DTg/LDTg (dorsal/laterodorsal tegmental n.), Ent (entorhinal cortex), GPe (external globus pallidus), GPi (internal globus pallidus/entopeduncular n.), Hb (habenula), I (insular cortex), IL (infralimbic cortex), La (lateral amygdala), LO (lateral orbital cortex), LP (lateral posterior thalamic n.), LS (lateral septum), M1, M2 (primary, secondary motor cortex), Me (medial amygdala), MS (medial septum), Pir (piriform cortex), PrL (prelimbic cortex), PtA (parietal association cortex), PTg (pedunculopontine tegmental n.), RPC (red n.), RS (retrosplenial cortex), S1DZ, S1FL, S1J, S1Tr, S1ULp, (primary somatosensory cortex: dysgranular, forelimb, jaw, trunk, lip), S2 (secondary somatosensory cortex), SC (superior colliculus), vermis (2nd, 3rd cerebellar simple lobule), V1, V2 (primary, secondary visual cortex), v-HPC (ventral hippocampus), VL (ventral lateral thalamic n.), VM (ventromedial thalamic n.), VMH (ventromedial hypothalamus), VPL/VPM (ventral posterolateral, ventral posteromedial thalamic nuclei), VP (ventral pallidum), VS (ventral subiculum), ZI (zona inserta).本图展示了未运动大鼠中脑损伤（Lesion）的主效应以及脑损伤×行走（Lesion×Walk）的交互效应，各组样本量如下：脑损伤/行走/无运动训练（Lesion/Walk/No-ET，n=9）、假手术/行走/无运动训练（Sham/Walk/No-ET，n=10）、脑损伤/静息/无运动训练（Lesion/Rest/No-ET，n=10）、假手术/静息/无运动训练（Sham/Rest/No-ET，n=9）。 同时还展示了脑损伤大鼠中运动训练（Exercise Training, ET）的主效应以及运动训练×行走（Exercise×Walk）的交互效应，各组样本量为：脑损伤/行走/无运动训练（n=9）、脑损伤/静息/无运动训练（n=10）、脑损伤/行走/运动训练（Lesion/Walk/ET，n=11）、脑损伤/静息/运动训练（Lesion/Rest/ET，n=12）。 所有条目均在体素水平标注了显著性（*），具体脑区及缩写对应如下：P[39]：5（三叉神经核、运动核、感觉核），aca（anterior commissures，前连合）、AHi（amygdalo-hippocampal area，杏仁核-海马区）、APir（amygdalo-piriform transition area，杏仁核-梨状过渡区）、BL（basolateral amygdala，基底外侧杏仁核）、Ce（central amygdalar nucleus，中央杏仁核）、Cg（cingulate cortex，扣带回皮层）、CM（central medial thalamic nucleus，中央内侧丘脑核）、CPu（striatum：anterior, ant-CPu；dorsal, d-CPu；ventral, v-CPu，纹状体：前部、前纹状体；背部、背纹状体；腹部、腹纹状体）、d-HPC（dorsal hippocampus，背侧海马）、DTg/LDTg（dorsal/laterodorsal tegmental nucleus，背侧/背外侧被盖核）、Ent（entorhinal cortex，内嗅皮层）、GPe（external globus pallidus，苍白球外侧部）、GPi（internal globus pallidus/entopeduncular nucleus，苍白球内侧部/内囊核）、Hb（habenula，缰核）、I（insular cortex，岛叶皮层）、IL（infralimbic cortex，边缘下皮层）、La（lateral amygdala，外侧杏仁核）、LO（lateral orbital cortex，外侧眶皮层）、LP（lateral posterior thalamic nucleus，后外侧丘脑核）、LS（lateral septum，外侧隔核）、M1、M2（primary, secondary motor cortex，初级、次级运动皮层）、Me（medial amygdala，内侧杏仁核）、MS（medial septum，内侧隔核）、Pir（piriform cortex，梨状皮层）、PrL（prelimbic cortex，前边缘皮层）、PtA（parietal association cortex，顶叶联合皮层）、PTg（pedunculopontine tegmental nucleus，脚桥被盖核）、RPC（red nucleus，红核）、RS（retrosplenial cortex，压后皮层）、S1DZ、S1FL、S1J、S1Tr、S1ULp（primary somatosensory cortex: dysgranular, forelimb, jaw, trunk, lip，初级躯体感觉皮层：颗粒不皮层区、前肢区、下颌区、躯干区、唇部区）、S2（secondary somatosensory cortex，次级躯体感觉皮层）、SC（superior colliculus，上丘）、小脑蚓部（第2、3小脑小叶）、V1、V2（primary, secondary visual cortex，初级、次级视觉皮层）、v-HPC（ventral hippocampus，腹侧海马）、VL（ventral lateral thalamic nucleus，腹外侧丘脑核）、VM（ventromedial thalamic nucleus，腹内侧丘脑核）、VMH（ventromedial hypothalamus，腹内侧下丘脑）、VPL/VPM（ventral posterolateral, ventral posteromedial thalamic nuclei，腹后外侧、腹后内侧丘脑核）、VP（ventral pallidum，腹侧苍白球）、VS（ventral subiculum，腹侧下托）、ZI（zona inserta，未定带）。