Lysine methyltransferase Kmt2d regulates naive CD8+ T cell activation-induced survival
收藏NIAID Data Ecosystem2026-05-01 收录
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资源简介：
Lysine specific methyltransferase 2D (Kmt2d) catalyzes the mono-methylation of histone 3 lysine 4 (H3K4me1) and plays a critical role in regulatory T cell generation via modulating Foxp3 gene expression. We utilized ChIPseq, RNAseq, and scRNAseq to show the role of Kmt2d in naive CD8+ T cell generation and survival. Generated T-cell specific Kmt2d knock out mice to investrigate the role of Kmt2d in CD8+ T cell function. Isolated naive CD8+ T cells from Kmt2d KO and Kmt2d WT mice to investigate the function of Kmt2d.
创建时间：
2023-04-12
