Diet-induced changes in gene expression of lean and obese mice in three different brain regions

By looking at the transcriptome of the hypothalamus, frontal cortex and striatum, we studied how the fine balance between the homeostatic and hedonic control of food intake can be influenced by diet For 8 weeks, lean group mice had access to standard chow (SC) mouse diet and obese group mice had a free choice access to SC and a chocolate-mixture diet (CM). Fontal cortex, striatum and hypothalamus, from lean and obese groups, were dissected upon completion of an 11-day test battery and total RNAs extracted.