Synopsis of published anti-HCV/E2 human monoclonals binding to all major HCV genotypes (1a, 1b, 2a, 2b, 3a, 4, 5, 6).

The E2 residues involved in the binding of each antibody are reported (those crucial for e20 binding are in bold and underlined). Only the concentrations giving 50% neutralization (IC50) against HCV pseudoparticles (HCVpp) derived from different genotypes, or against HCV cell culture (HCVcc) strains, are reported. Punctual IC50 values are not available for mAbs 1∶7 and A8 against HCVpp [35], and for CBH-5 and CBH-7 against HCVpp derived from genotypes 1a, 3a, 4, 5 and 6 [37], [42], [43], [50], [51]. E20 is the only monoclonal tested as Fab fragment.