Synopsis of published anti-HCV/E2 human monoclonals binding to all major HCV genotypes (1a, 1b, 2a, 2b, 3a, 4, 5, 6).
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The E2 residues involved in the binding of each antibody are reported (those crucial for e20 binding are in bold and underlined). Only the concentrations giving 50% neutralization (IC50) against HCV pseudoparticles (HCVpp) derived from different genotypes, or against HCV cell culture (HCVcc) strains, are reported. Punctual IC50 values are not available for mAbs 1∶7 and A8 against HCVpp [35], and for CBH-5 and CBH-7 against HCVpp derived from genotypes 1a, 3a, 4, 5 and 6 [37], [42], [43], [50], [51]. E20 is the only monoclonal tested as Fab fragment.
创建时间：
2009-12-11
