TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6

TNFAIP3 can remove K63-linked ubiquitin from TRAF6, which terminates signalling by Toll-like receptors (Boone et al. 2004). TNFAIP3 is essential for the termination of NFkappaB activation in response to multiple stimuli such as IL-1beta, TNF, IL-6, CD40 and lipopolysaccharide (LPS). Removal of K63-linked ubiquitin is not necessarily followed by K48-ubiquitination that would lead to degradation (Vereecke et al. 2009).

TNFAIP3能够移除与K63连接的泛素化修饰从TRAF6，从而终止Toll样受体的信号传导（Boone等人，2004年）。TNFAIP3对于响应多种刺激，如IL-1beta、TNF、IL-6、CD40和脂多糖（LPS）引起的NFkappaB激活的终止是必不可少的。K63连接的泛素化修饰的去除并不必然导致K48泛素化，进而引发降解（Vereecke等人，2009年）。