Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue

Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue Descriptor: (2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid, Sialic acid-binding Ig-like lectin 8 Authors: Lenza, M.P, Oyenarte, I, Atxabal, U, Nycholat, C, Franconetti, A, Quintana, J.I, Delgado, S, Unione, L, Paulson, J, Jimenez-Barbero, J, Ereno-Orbea, J. Deposit date: 2022-01-18 Release date: 2023-01-18 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.352 Å) Cite: Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody. Jacs Au, 3, 2023

Siglec-8（唾液酸结合免疫球蛋白样凝集素8，Sialic acid-binding Ig-like lectin 8）N端结构域与磺酰胺类唾液酸苷类似物（sulfonamide sialoside analogue）复合的晶体结构。
描述符：(2S,4S,5R,6R)-5-乙酰胺基-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-乙酰胺基-2-(羟甲基)-4,6-二羟基四氢吡喃-3-基]氧基-3,5-二羟基-6-(磺酰氧甲基)四氢吡喃-4-基]氧基-6-[(1R,2R)-3-(萘-2-磺酰胺基)-1,2-二羟基丙基]-4-羟基四氢吡喃-2-羧酸。
作者：Lenza, M.P.、Oyenarte, I.、Atxabal, U.、Nycholat, C.、Franconetti, A.、Quintana, J.I.、Delgado, S.、Unione, L.、Paulson, J.、Jimenez-Barbero, J.、Ereno-Orbea, J.
沉积日期：2022-01-18
发布日期：2023-01-18
最后修改日期：2024-10-16
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率3.352埃（Å）
引用文献：《抑制性受体Siglec-8与高亲和力唾液酸苷类似物及治疗性抗体的复合结构》，JACS Au，第3卷，2023年