Additional file 13 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide

Additional file 13. Table S7. Over-representation analysis (ORA) on upregulated genes in Cluster 1A compared to non-Cluster 1A tumours for Biological Process and Cellular Component gene ontology terms. Perturbed biological processes included “negative regulation of execution phase of apoptosis” (GO:1900118) with enrichment ratio (ER) 27.43 and FDR &lt; 0.001, “extracellular regulation of signal transduction” (GO:1900115, ER=16.625, FDR &lt; 0.001) and “regulation of transcription involved in cell fate commitment” (GO:0060850, ER=16.136, FDR=0.01).补充材料13，表S7。针对生物过程（Biological Process）与细胞组分（Cellular Component）两类基因本体（Gene Ontology, GO）术语，对聚类1A样本中相较于非聚类1A肿瘤样本的上调基因开展过表征分析（Over-representation analysis, ORA）。本次分析富集得到的扰动生物过程包括：「细胞凋亡执行阶段负调控」（GO:1900118），其富集比（Enrichment Ratio, ER）为27.43，错误发现率（False Discovery Rate, FDR）<0.001；「细胞外信号转导调控」（GO:1900115，ER=16.625，FDR<0.001）；以及「细胞命运决定相关转录调控」（GO:0060850，ER=16.136，FDR=0.01）。