ERBB2 promotes PTK6 autophosphorylation
收藏reactome.org2025-03-23 收录
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Binding of PTK6 (BRK) to activated ERBB2 receptor stimulates autophosphorylation of PTK6 on tyrosine residue Y342 (Xiang et al. 2008, Peng et al. 2015). Autophosphorylation at Y342 significantly increases catalytic activity of PTK6 (Qiu and Miller 2002).
PTK6(BRK)与激活的ERBB2受体的结合可诱导PTK6在酪氨酸残基Y342处的自磷酸化(参见Xiang等,2008年,Peng等,2015年)。Y342处的自磷酸化显著提升了PTK6的催化活性(Qiu与Miller,2002年)。
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