Evolution of Klebsiella pneumoniae with progressive sub-MIC cephalothin exposure

NIAID Data Ecosystem2026-03-13 收录

耐药性进化

肺炎克雷伯菌实验进化

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA854906 数据链接链接失效反馈

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Evolution of Klebsiella pneumoniae with progressive sub-MIC cephalothin exposure

创建时间：

2022-07-01

A trade-off for maintenance of multidrug-resistance IncHI2 plasmids in Salmonella Typhimurium through co-evolution

耐药性进化

宿主-质粒互作

Plasmid maintenance costs to bacterial hosts is closely linked to the mechanisms that underlie plasmid fitness and how these costs are resolved. Herein, we performed multiple (63) serial passage to ex

NIAID Data Ecosystem140

Positive Epistasis Drives the Acquisition of Multidrug Resistance

耐药性进化

正向上位效应

The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on the

NIAID Data Ecosystem100

Assemblies (zipped directory)

细菌基因组学

耐药性进化

1092 Klebsiella pneumoniae genome assemblies. These data are described in Wyres et al "Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pn

NIAID Data Ecosystem50

Evolutionary origin of the staphylococcal cassette chromosome mec (SCCmec). Evolution and assembly of a primordial SCCmec

耐药性进化

葡萄球菌基因组

Several lines of evidence indicate that the most primitive staphylococcal species, the Staphylococcus sciuri group, were involved in the first stages of evolution of SCCmec – the genetic element carry

NIAID Data Ecosystem110

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

耐药性进化

细菌动态药物选择

Antibiotic resistance can evolve through the sequential accumulation of multiple mutations. To study such gradual evolution, we developed a selection device, the 'morbidostat', that continuously monit

NIAID Data Ecosystem50

Evolution of Klebsiella pneumoniae with progressive sub-MIC cephalothin exposure

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