Preferential Selection of Isomer Binding from Chiral Mixtures: Alernate Binding Modes Observed fro the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase

Preferential Selection of Isomer Binding from Chiral Mixtures: Alernate Binding Modes Observed fro the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase Descriptor: 5-[(1E,3R)-2-(2-methoxyphenyl)-3-methylpent-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Cody, V. Deposit date: 2010-07-14 Release date: 2010-12-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 66, 2010

手性混合物中异构体结合偏好性选择：一系列5-取代2,4-二氨基呋喃并[2,3-d]嘧啶的E型与Z型异构体作为与烟酰胺腺嘌呤二核苷酸磷酸（NADPH）及人二氢叶酸还原酶形成的三元复合物的交替结合模式观察
描述符：5-[(1E,3R)-2-(2-甲氧基苯基)-3-甲基戊-1-烯-1-基]呋喃并[2,3-d]嘧啶-2,4-二胺、二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）
作者：Cody, V.
提交日期：2010-07-14
发布日期：2010-12-15
最后修改日期：2023-09-06
实验方法：X射线衍射（分辨率1.9 Å）
引用文献：手性混合物中异构体结合偏好性选择：一系列5-取代2,4-二氨基呋喃并[2,3-d]嘧啶的E型与Z型异构体作为与NADPH及人二氢叶酸还原酶形成的三元复合物的结合模式观察。发表于《Acta Crystallogr.,Sect.D》，第66卷，2010年