A non-surgical brain implant enabled through cell-electronics hybrid for focal neuromodulation

Bioelectronic implants for brain stimulation are used to treat brain disorders but require invasive surgery. To provide a non-invasive alternative, we report non-surgical implants consisting of immune cell–electronics hybrids, an approach we call Circulatronics. The devices can be delivered intravenously and traffic autonomously to regions of inflammation in brain, where they implant and affect neuromodulation, circumventing the need for surgery. To achieve suitable electronics, we designed and built subcellular-sized, wireless, photovoltaic electronic devices (SWEDs) that harvest optical energy with high power conversion efficiency. In mice, we demonstrate non-surgical implantation in inflamed brain region as an example of therapeutic target for several neural diseases, by employing monocytes as cells, covalently attaching them to the SWEDs and administering the resulting hybrids intravenously. We also demonstrate neural stimulation with 30 µm precision around the inflamed region. Thus..., , # A non-surgical brain implant enabled through cell-electronics hybrid for focal neuromodulation

Dataset DOI: [10.5061/dryad.pzgmsbd12](10.5061/dryad.pzgmsbd12)

## Description of the data and file structure

This dataset contains all files required to reproduce the results in the publication “Non-surgical Bioelectronic Implant for Targeted Focal Brain Stimulation.”

### Files and variables

#### File: Data.xlsx

**Description:** Source data for figures in the main text, extended data, and supplementary figures

##### Variables

* The following sheets are present in the data.xlsx file - each named and corresponding to the source data for the figures
* Fig. 2d-h
* Fig. 3c, Fig. 3g-i
* Fig. 4f-g
* Fig. 5a-f
* Fig. E1
* Fig. E2
* Fig. E3
* Fig. E5
* Fig. E7
* Fig. E9
* Fig. E10
* Fig. S5
* Fig. S6
* Fig. S9
* Fig. S11

#### File: Fig2b.zip

**Description:** Raw SEM images corresponding to the figure

#### File: FigE3.zip

**Description:** Raw SEM images corre...,

用于脑刺激的生物电子植入物可用于治疗脑部疾病，但需实施侵入性手术。为提供非侵入性替代方案，本研究报道了一种由免疫细胞-电子杂合体构成的非手术植入物，我们将该方法命名为循环电子学（Circulatronics）。该装置可通过静脉递送，并自主迁移至脑部炎症区域，在该处完成植入并实现神经调节，从而规避手术需求。为适配所需的电子系统，本研究设计并制备了亚细胞尺寸的无线光伏电子装置（subcellular-sized wireless photovoltaic electronic devices, SWEDs），该装置可通过高功率转换效率收集光能。在小鼠模型中，我们以单核细胞作为载体细胞，将其与SWEDs共价结合后通过静脉注射递送，成功在脑部炎症区域实现非手术植入，以此作为多种神经疾病治疗靶点的示例。本研究还实现了炎症区域周围30微米精度的神经刺激。综上……
# 基于细胞-电子杂合体实现的用于局灶性神经调节的非手术脑植入物

数据集DOI：[10.5061/dryad.pzgmsbd12](10.5061/dryad.pzgmsbd12)

## 数据与文件结构说明
本数据集包含复现论文《用于靶向局灶性脑刺激的非手术生物电子植入物》中所有结果所需的全部文件。

### 文件与变量

#### 文件：Data.xlsx
**说明：** 正文中图表、扩展数据及补充图表的源数据

##### 变量
* data.xlsx文件包含以下工作表，每个工作表均以对应图表命名，存储该图表的源数据：
* 图2d-h
* 图3c、图3g-i
* 图4f-g
* 图5a-f
* 扩展图E1
* 扩展图E2
* 扩展图E3
* 扩展图E5
* 扩展图E7
* 扩展图E9
* 扩展图E10
* 补充图S5
* 补充图S6
* 补充图S9
* 补充图S11

#### 文件：Fig2b.zip
**说明：** 对应图表的原始扫描电子显微镜（Scanning Electron Microscope, SEM）图像

#### 文件：FigE3.zip
**说明：** 原始扫描电子显微镜图像……