Notch signaling mediates Vegf<sub>120</sub>-induced coronary angiogenesis by the ventricular endocardial cells.
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A. A graph showing increased expression of 5 angiogenic/vascular endothelial genes in the E11.5 R1 CKO hearts. B-E, Images of E11.5 ventricular explants showing that Notch signaling inhibitor DAPT abolished the Vegf120-induced angiogenic branching (arrows) by the control (B, D) and R1 CKO endocardial cells (C, E). F, Statistical analysis showing that DAPT treatment significantly inhibits the endothelial branching by the control or R1 CKO endocardial cells. n = 5 ventricles, *p<0.05, error bars = SD.
创建时间:
2013-07-24



