Characteristics of animal experiments.

BackgroundNumerous recent studies have found a strong correlation between intestinal flora and the occurrence of hypertension. However, it remains unclear whether fecal microbiota transfer might affect the blood pressure of the host. This study aimed to quantify both associations.MethodsAn electronic search was conducted in PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang database, Weipu, Embase, and SinoMed to retrieve relevant studies. The final search was completed on August 22, 2022. Two authors independently applied the inclusion criteria, extracted data, and assessed the risk of bias assessment. All data were analyzed using RevMan 5.4.ResultsA total of 5 articles were selected for final inclusion. All studies were assessed as having a high risk of bias according to the SYRCLE risk of bias tool. The meta-analysis results showed that transplantation of fecal bacteria from the hypertensive model can significantly improve the host’s systolic pressure (MD = 18.37, 95%CI: 9.74~26.99, PPPPConclusionThis meta-analysis suggests a relationship between gut microbiota dysbiosis and increased blood pressure, where transplantation of fecal bacteria from the hypertensive model can cause a significant increase in systolic pressure and diastolic pressure in animal models.背景 近年来诸多研究均证实肠道菌群（intestinal flora）与高血压的发生存在显著相关性，但粪便菌群移植（fecal microbiota transfer）是否会影响宿主血压仍未明确。本研究旨在量化这两种关联。 方法 本研究通过PubMed、EMBASE、Cochrane图书馆、Web of Science、中国知网（China National Knowledge Infrastructure, CNKI）、万方数据库、维普数据库、EMBASE以及SinoMed进行电子检索，以获取相关研究。最终检索完成于2022年8月22日。由2名研究者独立执行纳入标准筛选、数据提取及偏倚风险评估。所有数据分析均采用RevMan 5.4软件完成。 结果 最终共纳入5篇文献。根据SYRCLE偏倚风险评估工具，所有研究均被评定为存在较高偏倚风险。本荟萃分析结果显示，高血压模型的粪便细菌移植可显著升高宿主收缩压（均数差MD=18.37，95%置信区间CI：9.74~26.99，PPPP）。 结论 本荟萃分析提示肠道微生物群失调与血压升高存在关联，高血压模型动物的粪便细菌移植可使动物模型的收缩压与舒张压显著升高。