Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET)

The TaRGET (Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription) Program is a research consortium funded by the National Institute of Environmental Health Sciences (NIEHS). The goal of the collaboration is to address the role of environmental exposures in disease pathogenesis as a function of epigenome perturbation, including understanding the environmental control of epigenetic mechanisms and assessing the utility of surrogate tissue analysis in mouse models of disease-relevant environmental exposures.

TaRGET（转录调控因子调控的毒物暴露与反应）项目是由美国国家环境卫生科学研究所（NIEHS）资助的研究联盟。该合作项目的宗旨在于探讨环境暴露在疾病发生发展中的作用，尤其是从表观基因组扰动角度理解环境对表观遗传机制的控制，并评估替代性组织分析在疾病相关环境暴露小鼠模型中的实用性。