Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
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Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, N-(furan-2-ylmethyl)quinoxaline-6-carboxamide, ... Authors: Silva-Santisteban, M.C, Westwood, I.M, Boxall, K, Brown, N, Peacock, S, McAndrew, C, Barrie, E, Richards, M, Mirza, A, Oliver, A.W, Burke, R, Hoelder, S, Jones, K, Aherne, G.W, Blagg, J, Collins, I, Garrett, M.D, van Montfort, R.L.M. Deposit date: 2012-10-05 Release date: 2013-06-26 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. Plos One, 8, 2013
基于片段的筛选发现细胞周期检查点激酶2（checkpoint kinase 2, CHK2）结合抑制剂的全新结合区域
描述物：1,2-乙二醇（1,2-ETHANEDIOL）、氯离子（CHLORIDE ION）、N-(呋喃-2-基甲基)喹喔啉-6-甲酰胺（N-(furan-2-ylmethyl)quinoxaline-6-carboxamide）……
作者：Silva-Santisteban, M.C.、Westwood, I.M.、Boxall, K.、Brown, N.、Peacock, S.、McAndrew, C.、Barrie, E.、Richards, M.、Mirza, A.、Oliver, A.W.、Burke, R.、Hoelder, S.、Jones, K.、Aherne, G.W.、Blagg, J.、Collins, I.、Garrett, M.D.、van Montfort, R.L.M.
提交日期：2012-10-05
发布日期：2013-06-26
最后修改日期：2023-12-20
实验方法：X射线衍射（3 Å）
引用文献：《基于片段的筛选绘制细胞周期检查点激酶2 ATP结合位点内的抑制剂相互作用图谱（Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2）》，发表于《公共科学图书馆·综合》（PLOS ONE），2013年，第8卷
创建时间：
2012-10-05
