Minimum dataset.

ObjectiveTo investigate the association between denture wearing and airflow limitation in men in Northern Ireland enrolled in the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study.MethodsA case-control design was used to study partially dentate men. Cases were men aged 58–72 years who were confirmed as denture wearers. Controls were never denture wearers who were matched by age (± 1 month) and smoking habit to the cases. The men had a periodontal assessment and completed a questionnaire detailing their medical history, dental history and behaviours, social circumstances, demographic background and tobacco use. Physical examination and spirometry measurements of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were also undertaken. Spirometry data for edentulous men who wore complete dentures were compared with that recorded for the partially dentate men studied.ResultsThere were 353 cases who were partially dentate and were confirmed denture wearers. They were matched for age and smoking habit to never denture wearer controls. The cases had an FEV1 that was on average 140 ml lower than the controls, p = 0.0013 and a 4% reduction in percent predicted FEV1, p = 0.0022. Application of the GOLD criteria indicated that 61 (17.3%) of the cases had moderate to severe airflow limitation compared with 33 (9.3%) of controls, p = 0.0051. Fully adjusted multivariable analysis showed that partially dentate men who were denture wearers were significantly more likely (p = 0.01) to have moderate to severe airflow reduction with an adjusted odds ratio (OR) of 2.37 (95% confidence intervals 1.23–4.55). In the 153 edentulous men studied moderate to severe airflow limitation was recorded in 44 (28.4%), which was significantly higher than in the partially dentate denture wearers (p = 0.017), and the men who had never worn a denture (pConclusionDenture wearing was associated with an increased risk of moderate to severe airflow limitation in the cohort of middle-aged Western European men studied.研究目标：纳入北爱尔兰地区参与心肌梗死前瞻性流行病学研究（Prospective Epidemiological Study of Myocardial Infarction，PRIME）的男性受试者，探讨义齿佩戴与气流受限之间的关联。 研究方法：本研究采用病例对照设计，针对部分缺牙男性开展研究。病例组为年龄58~72岁、经证实为义齿佩戴者的男性；对照组为从未佩戴义齿的男性，且按年龄（±1个月）与吸烟习惯与病例组进行匹配。所有受试者均接受牙周评估，并填写涵盖病史、牙科史及相关行为、社会状况、人口学背景与烟草使用情况的调查问卷。同时开展体格检查，以及一秒用力呼气容积（forced expiratory volume in one second，FEV1）和用力肺活量（forced vital capacity，FVC）的肺量测定。此外，本研究还将佩戴全口义齿的无牙男性的肺量测定数据与纳入的部分缺牙男性的测定数据进行对比。 研究结果：本研究共纳入353例部分缺牙且经证实为义齿佩戴者的男性作为病例组，按年龄与吸烟习惯匹配的从未佩戴义齿男性作为对照组。病例组的FEV1平均较对照组低140ml（p=0.0013），预测FEV1百分比降低4%（p=0.0022）。采用GOLD标准（Global Initiative for Chronic Obstructive Lung Disease）评估显示，61例（17.3%）病例组对象存在中重度气流受限，而对照组仅33例（9.3%），组间差异具有统计学意义（p=0.0051）。经完全校正的多变量分析结果显示，作为义齿佩戴者的部分缺牙男性出现中重度气流降低的风险显著升高（p=0.01），校正比值比（odds ratio，OR）为2.37（95%置信区间：1.23~4.55）。在本研究纳入的153例无牙男性中，44例（28.4%）存在中重度气流受限，该比例显著高于部分缺牙义齿佩戴者组（p=0.017）以及从未佩戴义齿的男性组（p 研究结论：在本次纳入的中年西欧男性队列中，义齿佩戴与中重度气流受限的风险升高存在显著关联。