Interleukin-6 and adhesion molecules VCAM-1 and ICAM-1 as biomarkers of post-acute myocardial infarction heart failure

Acute coronary syndromes are associated with a high prevalence of complications including heart failure (HF). The aim of this study was to investigate the association of novel biomarkers with the occurrence of post-acute myocardial infarction (AMI) HF. A prospective study was conducted with patients admitted to the emergency department with ST-segment elevation myocardial infarction (STEMI). Blood and urine samples were collected for analysis of traditional and novel biomarkers, including interleukin-6, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1). We compared the levels of these biomarkers between patients with and without post-STEMI HF. A total of 48 patients were assessed, with a prevalence of males. Fifteen patients (31.2%) had post-STEMI HF. Patients with HF had higher mean values of IL-6, VCAM-1, and ICAM-1 compared to those who did not develop HF (57.06 vs 14.03 pg/mL, P=0.001; 1719.58 vs 1304.34 ng/mL, P=0.001; and 1594.20 vs 1158.74 ng/mL, P急性冠状动脉综合征常伴随较高的并发症发生率，其中包括心力衰竭（HF）。本研究旨在探讨新型生物标志物与急性心肌梗死后（AMI）心力衰竭发生的关联。本研究针对急诊科收治的ST段抬高型心肌梗死（STEMI）患者开展了一项前瞻性研究。采集血液与尿液样本，用于分析传统及新型生物标志物，包括白细胞介素-6（interleukin-6）、血管细胞黏附分子1（VCAM-1）以及细胞间黏附分子1（ICAM-1）。对比了发生与未发生STEMI后心力衰竭患者的上述生物标志物水平。本研究共纳入48例患者进行评估，其中男性占一定比例。共有15例患者（31.2%）发生了STEMI后心力衰竭。与未发生心力衰竭的患者相比，发生心力衰竭的患者其白细胞介素-6、VCAM-1及ICAM-1的平均水平更高（分别为57.06 vs 14.03 pg/mL，P=0.001；1719.58 vs 1304.34 ng/mL，P=0.001；1594.20 vs 1158.74 ng/mL，P）。