Supplementary Material for: Admission Hemoglobin Is Prognostic for In-Hospital Mortality in Oldest-Old Patients with Acute Ischemic Stroke

Introduction: Anemia is a common condition encountered in acute ischemic stroke, and only a few pieces of evidence has been produced suggesting its possible association with short-term mortality have been produced. The study sought to assess whether admission anemia status had any impact on short-term clinical outcome among oldest-old patients with acute ischemic stroke. Materials and Methods: A retrospective review of Electronic Medical Recording System was performed in 2 tertiary hospitals. Data, from the oldest-old patients aged > = 80 years consecutively admitted with a diagnosis of acute ischemic stroke between January 1, 2015, and December 31, 2019, were analyzed. Admission hemoglobin was used as indicator for anemia and severity. Univariate and multivariate regression analyses were used to compare in-hospital mortality and length of in-hospital stay in different anemia statuses and normal hemoglobin patients. Results: A total of 705 acute ischemic stroke patients were admitted, and 572 were included in the final analysis. Of included patients, 240 of them were anemic and 332 nonanemic patients. A statistical difference between the 2 groups was found in in-hospital mortality (p p = 0.003) and 7.15 (95% CI: 1.46–34.90, p = 0.015) in moderate and severely anemic patients, respectively. Similarly, length of in-hospital stay was longer in anemic patients (21.64 ± 6.17 days) than in nonanemic patients (19.08 ± 5.48 days, p Conclusions: Increased severity of anemia may be an independent risk factor for increased in-hospital mortality and longer length of stay in oldest-old patients with acute ischemic stroke.引言：贫血（anemia）是急性缺血性脑卒中常见的伴随病症，目前仅有少量研究证据提示其可能与短期死亡率存在关联。本研究旨在探讨入院时的贫血状态对≥80岁高龄老年急性缺血性脑卒中患者短期临床结局的影响。 材料与方法：本研究在两家三级医院开展，对其电子病历系统（Electronic Medical Recording System）数据进行回顾性分析。研究对象为2015年1月1日至2019年12月31日期间连续收治的、年龄≥80岁的急性缺血性脑卒中高龄老年患者，最终对其临床数据展开分析。以入院时的血红蛋白水平作为贫血及其严重程度的判定指标。采用单因素回归分析与多因素回归分析，对比不同贫血状态患者与血红蛋白水平正常患者的院内死亡率及住院时长。 结果：本研究共收治705例急性缺血性脑卒中患者，最终572例纳入最终分析。其中贫血患者240例，非贫血患者332例。两组患者的院内死亡率存在统计学差异（p=0.003）；中重度贫血患者的院内死亡风险比值比为7.15（95%置信区间：1.46~34.90，p=0.015）。同样，贫血患者的住院时长为21.64±6.17天，长于非贫血患者的19.08±5.48天，p 结论：贫血严重程度升高可能是≥80岁高龄老年急性缺血性脑卒中患者院内死亡率升高及住院时长延长的独立危险因素。